Ulland, T.K. and Colonna, M. TREM2, a Key Player in Microglia Biology and Alzheimer’s Disease. Invited review for Nat. Rev. Neurol.Accepted.

Zhou, Y., Ulland, T.K., and Colonna, M.Trem2-dependent effects on microglia in Alzheimer’s Disease. Front. Aging Neurosci.  Published online Jun. 20, 2018.

Ulrich J.D.*, Ulland, T.K.*, Mahan, T.E.*, Nilsson, P., Song, W., Jiang, H., Stewart, F., Anderson, E., Wang, Y., Colonna, M., and Holtzman, D.M. ApoE Facilitates the Microglial Response to Amyloid Pathology. J. Exp. Med.215, 1047-1058, 2018. * indicates equal contribution.

Song, W.*, Joshita, S.*, Zhou, Y., Ulland, T.K., Gilfillan, S., and Colonna, M. Humanized TREM2 mice reveal microglia-intrinsic and –extrinsic loss of function effects of R47H polymorphism.  J. Exp. Med.215, 745-760, 2018.  * indicates equal contribution.

Robinette, M.L. Cella, M., Telliez, J.B., Ulland, T.K., Barrow, A.D., Capuder, A., Gilfillan, S.,  Lin, L-L., Notarangelo, L.D., and Colonna, M.Jak3 deficiency blocks innate lymphoid cell development. Mucosal Immunol. 11, 50-60, 2018.


Clay, G.C., Graff, J.W., Ulland, T.K.,Valadares, D., Davis, R.E., Scorza, B.M., Sudan, B., Sutterwala, F.S., and Wilson, M.E. Anti-inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis.  J. Immunol. 199, 2823-2833, 2017.

Ulland, T.K.*,Song,W.*, Huang, S.C., Ulrich, J.D., Sergushichev, A., Beatty, W.L., Cairns, N.J., Kambal, A., Loginicheva, E.,Gilfillan, S., Cella, M., Virgin, H.W., Unanue, E.R., Holtzman, D.M., Artyomov, M.N., and Colonna, M.  TREM2 is Required to Meet the Metabolic Demands of Microglia in Alzheimer’s Disease.  Cell 170, 649-663, 2017.* indicates equal contribution.Previewed in Hong, S. and Stevens, B. Cell Metab.26 (4), 590-591, 2017.

Cortez, V., Ulland, T.K., Bando, J., Robinette, M., Wang, Q., White, A.J., Gilfillan, S., Cella, M., and Colonna, M. SMAD4 Impedes Conversion of NK Cells into ILC1-like Cells by Curtailing        Non-canonical TGFβ Signaling. Nat. Immunol. Published online ahead of print July 31, 2017.

Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir, R., Ulland, T.K., David, E., Baruch,      K., Lara-Astaiso, D., Toth, B., Itzkovitz, S., Colonna, M., Schwartz, M., Amit, I. Single Cell RNA-seq Identifies a Unique Microglia Type Associated with Alzheimer’s Disease. CellJun 15; 169(7): 1276-1290, 2017. Featured in a Perspective in Science (356, 1123-1124, 2017) and a Preview in Cell (Jun 15 169(7): 1172-1174, 2017).

Ulrich, J.D., Ulland, T.K., Colonna, M., and Holtzman, D.M. Elucidating the role of TREM2 in Alzheimer’s disease. Neuron. Apr 19; 94(2): 237-248, 2017.

Song, W., Hooli, B., Mullin K., Jin S.C., Cella M., Ulland T.K., Wang Y., Tanzi R., Colonna M. Alzheimer’s Disease-associated TREM2 Variants Exhibit Either Decreased or Increased Ligand-dependent Activation.Alzheimer’s Dement. Apr; 13(4): 381-387, 2017.  Will be featured in News and Views of Nat. Rev. Neurol.

Robinette, M.L., Bando, J.K., Song, W., Ulland, T.K., Gilfillan, S., and Colonna, M.IL-15 Sustains IL-7R-Independent ILC2 and ILC3 Development. Nat. Commun.Mar 31;8:14601, 2017.


Ulland, T.K.*, Jain, N.*, Hornick, E.E., Elliott, E.I., Clay, G.C., Sadler, J., Mills, K.A.M., Janowski, A.M., Volk, A.P.D., Wang, K., Legge, K.L., Lokesh, G., Bourdi, M., Ferguson, P.J., Wilson, M.E., Cassel, S.L., Sutterwala, F.S. Nlrp12Mutation in C57BL/6J Mice Results in a Substrain-specific Defect in    Neutrophil Recruitment. * indicates equal contribution.  Nat. Commun. Oct; 7: 13180, 2016.

Wang, Y.*, Ulland, T.K.*,Ulrich, J.D.*, Song, W., Yuan, P., Mahan, T.E., Shi, Y., Gilfillan, S., Cella, M., DeMattos, R.B., Grutzendler, J., Cirrito, J.R., Holtzman, D.M.#, and Colonna, M.#  TREM2-mediated Early Microglial Response Limits Diffusion and Toxicity of Amyloid Plaques. * indicates equal contribution. # indicates co-corresponding authors. J. Exp. Med.Apr; 213(5): 667-675, 2016.  Featured on the cover.

Ulland, T.K.,Wang, Y., and Colonna, M. Regulation of Microglial Survival and Proliferation in Health and Diseases.  Semin. Immunol.Dec; 27(6): 410-415, 2015.

Wang, Y., Bugatti, M., Ulland, T.K., Vermi, W., Gilfillan, S., and Colonna, M. Non-redundant Roles of            Keratinocyte-derived IL-34 and Neutrophil-derived CSF1 in Langerhans Cells Renewal in the          Steady-state and Skin Inflammation.  Eur. J. Immunol. Mar; 46(3): 552-559, 2016.


Ulland, T.K., Ferguson, P.J.,and Sutterwala, F.S. Modulation of Inflammasome Activation by Microbial         Pathogens as a Survival Strategy: the Consequences of Evasion.  J. Clin. Invest. Feb; 125(2): 469-           477, 2015.


Chen, G., Wang, X., Severo, M.S., Sakhon, O.S., Sohail, M., Brown, L.J., Sircar, M., Snyder, G.A., Sundberg, E.J., Ulland, T.K., Olivier, A.K., Andersen, J.F., Zhou, Y., Shi, G., Sutterwala, F.S., Kotsyfakis, M., Pedra, J.H.F. The Tick Salivary Protein Sialostatin L2 Inhibits Caspase-1-Mediated        Inflammation during Anaplasma phagocytophilumInfection. Infect. Immun.Jun; 82(6): 2553-2564, 2014. 


Ulland, T.K.*, Janowski, A.M.*, Buchan, B.W., Cassel, S.L., Jones, B.D., and Sutterwala, F.S.  Francisella tularensisLVS Folate Metabolism and Pseudouridine Synthase Gene Mutants Modulate Macrophage Caspase-1 Activation.  Infect. Immun.Jan; 81(1): 201-208, 2013.


Ulland, T.K. and Sutterwala F.S. Activation of the Inflammasome by Bacterial Pathogens.  Invited book         chapter for The Inflammasomes2011.


Ulland, T.K., Buchan, B.W., Ketterer, M.R., Fernandes-Alnemri, T., Myerholz, D.K., Apicella, M.A., Alnemri, E.S., Jones, B.D., Nauseef, W.M., and Sutterwala, F.S.  Cutting Edge: Mutation of FrancisellatularensismviNLeads to Increased Macrophage Absent in Melanoma 2 Inflammasome Activation and Loss of Virulence. J. Immunol.Sep 1; 185(5): 2670-2674, 2010.


Iyer, S.S., Pulskens, W.P., Sadler, J.J., Butter, L.M., Teske, G.J., Ulland, T.K.,Eisenbarth, S.C., Florquin, S., Flavell, R.A., Leemans, J.C., and Sutterwala, F.S. Necrotic Cells Trigger a Sterile Inflammatory Response Through the NLRP3 Inflammasome. Proc. Natl. Acad. Sci. Dec; 106(48): 20388-93, 2009.

Moreland, J. G., Hook, J. S., Bailey, G., Ulland,T.,and Nauseef, W.M. Francisella tularensis Directly             Interacts with the Endothelium and Recruits Neutrophils with a Blunted Inflammatory Phenotype. Am. J. Physiol. Lung Cell. Mol. Physio. Jun; 296(6):L1076-84, 2009.