Publications

2024

Shippy, D.C., Oliai, S.F., and Ulland, T.K. Zinc Utilization by Microglia in Alzheimer’s Disease. J. Biol. Chem., 300, 5, article number 107306. doi:10.1016/j.jbc.2024.107306, 2024.

Oliai, S.F., Shippy, D.C., and Ulland, T.K. Mitigation of CXCL10 by Metabolic Disorder Drugs in Microglial-mediated Neuroinflammation. J. Neuroimmunol. 391, article 578364. doi:10.1016/j.neuroim.2024.578364, 2024.

2023

Heston, M.*, Hanslik, K.*, Zarbock, K.R.*, Harding, S.J., Davenport-Sis, N.J., Kerby, R.L., Chin, N., Sun, Y., Hoeft, A, Deming, Y., Vogt, N., Betthauser, T.J., Johnson, S.C., Asthana, S., Kollmorgen, G., Suridjan, I., Wild, N., Zetterberg, H., Blennow, K., Rey, F.E.⁺, Bendlin, B.B.⁺, and Ulland, T.K.⁺ Gut Inflammation Associated with Age and Alzheimer’s Disease Pathology. Sci. Rep., 13: article 18924.* indicates equal contribution. ⁺ indicates co-contributing authors. doi: 10.1038/s41598-023-45929-z, 2023.

Shippy, D.C. and Ulland T.K. Genome-wide Identification of Murine Interferon Genes in Microglial-mediated Neuroinflammation in Alzheimer’s Disease. J. Neuroimmunol., 375, article 578031. doi.org/10.1016/j.jneuroim.2023.578031, 2023.

Ennerfelt, H., Holliday, C., Shapiro, D.A., Zengeler, K.E., Bolte, A.C., Ulland, T.K., and Lukens, J.R. CARD9 Attenuates Ab Pathology and Modifies Microglial Responses in an Alzheimer’s Disease Mouse Model. Proc. Natl. Acad. Sci., 120:24 e2303760120. doi.org/10.1073/pnas.2303760120, 2023.

Shippy, D.C. and Ulland, T.K. Lipid Metabolism Transcriptomics of Murine Microglia in Alzheimer’s Disease and Neuroinflammation. Sci. Rep., 13: article 14800. doi:10.1038/s41598-023-41897-6, 2023.

2022

Ennerfelt, H., Frost, E.L., Shapiro, D.A., Holliday, C., Voithofer, G., Zengeler, K.E., Kulas, J.A., Ulland, T.K., and Lukens, J.R. SYK Coordinates Neuroprotective Microglial Responses in Neurodegenerative Disease. Cell, 185, 4135-4152.E22, doi.org/10.1016/j.cell.2022.09.030, 2022.

Zarbock, K.R., Han, J.H., Singh, A.P., Thomas, S.P., Bendlin, B.B., Denu, J., Yu, J.-P.J., Rey, F.E.*, and Ulland, T.K.* Trimethylamine N-oxide Reduces Neurite Density and Plaque Intensity in a Murine Model of Alzheimer’s Disease. * indicates co-contributing authors. J Alzheimer’s Dis., 90, 585-597, doi.org/10.3233/JAD-220413, 2022.

Shippy, D.C. and Ulland, T.K. Exploring the Transcriptional Landscape of Zinc in Alzheimer’s Disease. IBRO Neurosci. Reports, 13, 31-37, doi.org/10.1016/j.ibneur.2022.06.002, 2022.

Haynes, E.M., Ulland, T.K., and Eliceiri, K.W. A Model of Discovery: The Role of Imaging Established and Emerging Non-mammalian Models in Neuroscience. Front. Mol. Neurosci., Vol.: 15, Article 867010, doi:10.3389/fnmol.2022.867010, 2022.

2021

Dvir-Szternfeld, R., Castellani, G., Arad, M., Cahalon, L., Colaiuta, S., Keren-Shaul, H., Croese, T., Burgaletto, C., Baruch, K., Ulland, T., Colonna, M., Weiner, A., Amit, I., and Schwartz, M. Alzheimer’s Disease Modification Mediated by Bone Marrow-derived Macrophages via a TREM2-independent Pathway in Mouse Model of Amyloidosis.  Nat. Aging, Published online on December 20, 2021.

Ulland, T.K., Ewald, A., Knutson, A.O., Marino, K.M., Smith, S.M., and Watters, J.J. Alzheimer’s disease, sleep disordered breathing and microglia: puzzling out a common link. Cells, 10(11), 2907, doi.org/10.3390/cells10112907, 2021.

Hanslik, K.L., Marino, K.M., and Ulland, T.K. Modulation of glial function in health, aging, and neurodegenerative disease. Front. Cell. Neurosci., Vol.: 15, Article 718324, doi:10.3389/fncel.2021.718324, 2021

2020

Shippy, D.C., Wilhelm, C., Viharkumar, P.A., Raife, T.J., and Ulland, T.K.  b-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer’s disease pathology. J. Neuroinflammation., Vol.: 17, Article: 280, doi.org/10.1186/s12974-020-01948-5, 2020.

Shippy, D.C. and Ulland, T.K. Microglial Immunometabolism in Alzheimer’s disease. Front. Cell. Neurosci., Vol.: 14, Article: 563446, doi: 10.3389/fncel.2020.563446, 2020.

Hanslik, K.L. and Ulland, T.K.  The role of microglia and the Nlrp3 inflammasome in Alzheimer’s disease.  Front. Neurol., Vol.: 11, Article: 570711, doi: 10.3389/fneur.2020.570711, 2020.

Zhou, Y., Song, W.M., Andhey P.S., Swain, A., Levy, T., Miller, K.R., Poliani, P.L., Cominelli, M., Grover, S., Gilfillan, S., Cella, M., Ulland, T.K., Zaitsev, K., Miyashita, A., Ikeuchi, T., Sainouchi, M., Kakita, A., Bennett, D.A., Schneider, J.A., Nichols, M.R., Beausoleil, S.A., Ulrich, J., Holtzman, D.M., Artyomov, M.N., and Colonna, M.  Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and -independent cellular responses in Alzheimer’s disease. Nat. Med., 26, 131-142, 2020.

2019

Ardain, A., Domingo-Gonzalez, R., Das, S., Kazer, S.W., Howard, N.C., Singh, A., Ahmed, M.,Nhamoyebonde, S., Rangel0Moreno, J., Ogongo, P., Lu, L., Ramsuran, D., Garcia-Hernandez, M.L., Ulland, T.K., Darby, M., Park, E., Karim, F., Melocchi, L., Madansein, R., Dullabh, K.J., Dunlap, M., Marin-Agudelo, N., Ebihara, T., Ndung’u, T., Kaushal, D., Pym, A.S., Kolls, J.K., Steyn, A., Zuniga, J., Horsnell, W., Yokoyama, W., Shalek, A.K., Kloverpris, H.N., Colonna, M., Leslie, A., and Khader, S.A. Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis. Nature, 572, E10, 2019.

2018

Ulland, T.K. and Colonna, M. TREM2, a Key Player in Microglia Biology and Alzheimer’s Disease. Invited review for Nat. Rev. Neurol., 14, 667-675, 2018.

Zhou, Y., Ulland, T.K., and Colonna, M.Trem2-dependent effects on microglia in Alzheimer’s Disease. Front. Aging Neurosci., 10, 202 eCollection, 2018.

Ulrich J.D.*, Ulland, T.K.*, Mahan, T.E.*, Nilsson, P., Song, W., Jiang, H., Stewart, F., Anderson, E., Wang, Y., Colonna, M., and Holtzman, D.M. ApoE Facilitates the Microglial Response to Amyloid Pathology. * indicates equal contribution. J. Exp. Med., 215, 1047-1058, 2018.

Song, W.*, Joshita, S.*, Zhou, Y., Ulland, T.K., Gilfillan, S., and Colonna, M. Humanized TREM2 mice reveal microglia-intrinsic and –extrinsic loss of function effects of R47H polymorphism.  J. Exp. Med.,215, 745-760, 2018.  * indicates equal contribution.

Robinette, M.L. Cella, M., Telliez, J.B., Ulland, T.K., Barrow, A.D., Capuder, A., Gilfillan, S.,  Lin, L-L., Notarangelo, L.D., and Colonna, M.Jak3 deficiency blocks innate lymphoid cell development. Mucosal Immunol., 11, 50-60, 2018.

2017

Clay, G.C., Graff, J.W., Ulland, T.K.,Valadares, D., Davis, R.E., Scorza, B.M., Sudan, B., Sutterwala, F.S., and Wilson, M.E. Anti-inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis.  J. Immunol., 199, 2823-2833, 2017.

Ulland, T.K.*, Song,W.*, Huang, S.C., Ulrich, J.D., Sergushichev, A., Beatty, W.L., Cairns, N.J., Kambal, A., Loginicheva, E.,Gilfillan, S., Cella, M., Virgin, H.W., Unanue, E.R., Holtzman, D.M., Artyomov, M.N., and Colonna, M.  TREM2 is Required to Meet the Metabolic Demands of Microglia in Alzheimer’s Disease. * indicates equal contribution. Cell,170, 649-663, 2017.Previewed in Hong, S. and Stevens, B. Cell Metab., 26 (4), 590-591, 2017.

Cortez, V., Ulland, T.K., Bando, J., Robinette, M., Wang, Q., White, A.J., Gilfillan, S., Cella, M., and Colonna, M. SMAD4 Impedes Conversion of NK Cells into ILC1-like Cells by Curtailing Non-canonical TGFβ Signaling. Nat. Immunol., 18(9): 995-1003, 2017.

Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir, R., Ulland, T.K., David, E., Baruch,      K., Lara-Astaiso, D., Toth, B., Itzkovitz, S., Colonna, M., Schwartz, M., Amit, I. Single Cell RNA-seq Identifies a Unique Microglia Type Associated with Alzheimer’s Disease. Cell, Jun 15; 169(7): 1276-1290, 2017. Featured in a Perspective in Science (356, 1123-1124, 2017) and a Preview in Cell (Jun 15 169(7): 1172-1174, 2017).

Ulrich, J.D., Ulland, T.K., Colonna, M., and Holtzman, D.M. Elucidating the role of TREM2 in Alzheimer’s disease. Neuron, Apr 19; 94(2): 237-248, 2017.

Song, W., Hooli, B., Mullin K., Jin S.C., Cella M., Ulland T.K., Wang Y., Tanzi R., Colonna M. Alzheimer’s Disease-associated TREM2 Variants Exhibit Either Decreased or Increased Ligand-dependent Activation. Alzheimer’s Dement., Apr; 13(4): 381-387, 2017.

Robinette, M.L., Bando, J.K., Song, W., Ulland, T.K., Gilfillan, S., and Colonna, M.IL-15 Sustains IL-7R-Independent ILC2 and ILC3 Development. Nat. Commun., Mar 31;8:14601, 2017.

 2016

Ulland, T.K.*, Jain, N.*, Hornick, E.E., Elliott, E.I., Clay, G.C., Sadler, J., Mills, K.A.M., Janowski, A.M., Volk, A.P.D., Wang, K., Legge, K.L., Lokesh, G., Bourdi, M., Ferguson, P.J., Wilson, M.E., Cassel, S.L., Sutterwala, F.S. Nlrp12Mutation in C57BL/6J Mice Results in a Substrain-specific Defect in    Neutrophil Recruitment. * indicates equal contribution.  Nat. Commun., Oct; 7: 13180, 2016.

Wang, Y.*, Ulland, T.K.*,Ulrich, J.D.*, Song, W., Yuan, P., Mahan, T.E., Shi, Y., Gilfillan, S., Cella, M., DeMattos, R.B., Grutzendler, J., Cirrito, J.R., Holtzman, D.M.#, and Colonna, M.#  TREM2-mediated Early Microglial Response Limits Diffusion and Toxicity of Amyloid Plaques. * indicates equal contribution. # indicates co-corresponding authors. J. Exp. Med., Apr; 213(5): 667-675, 2016.  Featured on the cover.

Ulland, T.K.,Wang, Y., and Colonna, M. Regulation of Microglial Survival and Proliferation in Health and Diseases.  Semin. Immunol., Dec; 27(6): 410-415, 2015.

Wang, Y., Bugatti, M., Ulland, T.K., Vermi, W., Gilfillan, S., and Colonna, M. Non-redundant Roles of Keratinocyte-derived IL-34 and Neutrophil-derived CSF1 in Langerhans Cells Renewal in the Steady-state and Skin Inflammation.  Eur. J. Immunol., Mar; 46(3): 552-559, 2016.

2015

Ulland, T.K., Ferguson, P.J.,and Sutterwala, F.S. Modulation of Inflammasome Activation by Microbial Pathogens as a Survival Strategy: the Consequences of Evasion.  J. Clin. Invest., Feb; 125(2): 469-477, 2015.

2014

Chen, G., Wang, X., Severo, M.S., Sakhon, O.S., Sohail, M., Brown, L.J., Sircar, M., Snyder, G.A., Sundberg, E.J., Ulland, T.K., Olivier, A.K., Andersen, J.F., Zhou, Y., Shi, G., Sutterwala, F.S., Kotsyfakis, M., Pedra, J.H.F. The Tick Salivary Protein Sialostatin L2 Inhibits Caspase-1-Mediated Inflammation during Anaplasma phagocytophilum Infection. Infect. Immun., Jun; 82(6): 2553-2564, 2014.

2013

Ulland, T.K.*, Janowski, A.M.*, Buchan, B.W., Cassel, S.L., Jones, B.D., and Sutterwala, F.S.  Francisella tularensisLVS Folate Metabolism and Pseudouridine Synthase Gene Mutants Modulate Macrophage Caspase-1 Activation.  Infect. Immun., Jan; 81(1): 201-208, 2013.

2011

Ulland, T.K. and Sutterwala F.S. Activation of the Inflammasome by Bacterial Pathogens.  Invited book chapter for The Inflammasomes, 2011.

2010

Ulland, T.K., Buchan, B.W., Ketterer, M.R., Fernandes-Alnemri, T., Myerholz, D.K., Apicella, M.A., Alnemri, E.S., Jones, B.D., Nauseef, W.M., and Sutterwala, F.S.  Cutting Edge: Mutation of FrancisellatularensismviNLeads to Increased Macrophage Absent in Melanoma 2 Inflammasome Activation and Loss of Virulence. J. Immunol., Sep 1; 185(5): 2670-2674, 2010.

2009

Iyer, S.S., Pulskens, W.P., Sadler, J.J., Butter, L.M., Teske, G.J., Ulland, T.K.,Eisenbarth, S.C., Florquin, S., Flavell, R.A., Leemans, J.C., and Sutterwala, F.S. Necrotic Cells Trigger a Sterile Inflammatory Response Through the NLRP3 Inflammasome. Proc. Natl. Acad. Sci., Dec; 106(48): 20388-93, 2009.

Moreland, J. G., Hook, J. S., Bailey, G., Ulland,T.,and Nauseef, W.M. Francisella tularensis Directly Interacts with the Endothelium and Recruits Neutrophils with a Blunted Inflammatory Phenotype. Am. J. Physiol. Lung Cell. Mol. Physio., Jun; 296(6):L1076-84, 2009.