2021
Dvir-Szternfeld, R., Castellani, G., Arad, M., Cahalon, L., Colaiuta, S., Keren-Shaul, H., Croese, T., Burgaletto, C., Baruch, K., Ulland, T., Colonna, M., Weiner, A., Amit, I., and Schwartz, M. Alzheimer’s Disease Modification Mediated by Bone Marrow-derived Macrophages via a TREM2-independent Pathway in Mouse Model of Amyloidosis. Nat. Aging, Published online on December 20, 2021.
Ulland, T.K., Ewald, A., Knutson, A.O., Marino, K.M., Smith, S.M., and Watters, J.J. Alzheimer’s disease, sleep disordered breathing and microglia: puzzling out a common link. Cells, 10(11), 2907, doi.org/10.3390/cells10112907, 2021.
Hanslik, K.L., Marino, K.M., and Ulland, T.K. Modulation of glial function in health, aging, and neurodegenerative disease. Front. Cell. Neurosci., Vol.: 15, Article 718324, doi:10.3389/fncel.2021.718324, 2021
2020
Shippy, D.C., Wilhelm, C., Viharkumar, P.A., Raife, T.J., and Ulland, T.K. b-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer’s disease pathology. J. Neuroinflammation., Vol.: 17, Article: 280, doi.org/10.1186/s12974-020-01948-5, 2020.
Shippy, D.C. and Ulland, T.K. Microglial Immunometabolism in Alzheimer’s disease. Front. Cell. Neurosci., Vol.: 14, Article: 563446, doi: 10.3389/fncel.2020.563446, 2020.
Hanslik, K.L. and Ulland, T.K. The role of microglia and the Nlrp3 inflammasome in Alzheimer’s disease. Front. Neurol., Vol.: 11, Article: 570711, doi: 10.3389/fneur.2020.570711, 2020.
Zhou, Y., Song, W.M., Andhey P.S., Swain, A., Levy, T., Miller, K.R., Poliani, P.L., Cominelli, M., Grover, S., Gilfillan, S., Cella, M., Ulland, T.K., Zaitsev, K., Miyashita, A., Ikeuchi, T., Sainouchi, M., Kakita, A., Bennett, D.A., Schneider, J.A., Nichols, M.R., Beausoleil, S.A., Ulrich, J., Holtzman, D.M., Artyomov, M.N., and Colonna, M. Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and -independent cellular responses in Alzheimer’s disease. Nat. Med., 26, 131-142, 2020.
2019
Ardain, A., Domingo-Gonzalez, R., Das, S., Kazer, S.W., Howard, N.C., Singh, A., Ahmed, M.,Nhamoyebonde, S., Rangel0Moreno, J., Ogongo, P., Lu, L., Ramsuran, D., Garcia-Hernandez, M.L., Ulland, T.K., Darby, M., Park, E., Karim, F., Melocchi, L., Madansein, R., Dullabh, K.J., Dunlap, M., Marin-Agudelo, N., Ebihara, T., Ndung’u, T., Kaushal, D., Pym, A.S., Kolls, J.K., Steyn, A., Zuniga, J., Horsnell, W., Yokoyama, W., Shalek, A.K., Kloverpris, H.N., Colonna, M., Leslie, A., and Khader, S.A. Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis. Nature, 572, E10, 2019.
2018
Ulland, T.K. and Colonna, M. TREM2, a Key Player in Microglia Biology and Alzheimer’s Disease. Invited review for Nat. Rev. Neurol., 14, 667-675, 2018.
Zhou, Y., Ulland, T.K., and Colonna, M.Trem2-dependent effects on microglia in Alzheimer’s Disease. Front. Aging Neurosci., 10, 202 eCollection, 2018.
Ulrich J.D.*, Ulland, T.K.*, Mahan, T.E.*, Nilsson, P., Song, W., Jiang, H., Stewart, F., Anderson, E., Wang, Y., Colonna, M., and Holtzman, D.M. ApoE Facilitates the Microglial Response to Amyloid Pathology. J. Exp. Med.,215, 1047-1058, 2018. * indicates equal contribution.
Song, W.*, Joshita, S.*, Zhou, Y., Ulland, T.K., Gilfillan, S., and Colonna, M. Humanized TREM2 mice reveal microglia-intrinsic and –extrinsic loss of function effects of R47H polymorphism. J. Exp. Med.,215, 745-760, 2018. * indicates equal contribution.
Robinette, M.L. Cella, M., Telliez, J.B., Ulland, T.K., Barrow, A.D., Capuder, A., Gilfillan, S., Lin, L-L., Notarangelo, L.D., and Colonna, M.Jak3 deficiency blocks innate lymphoid cell development. Mucosal Immunol., 11, 50-60, 2018.
2017
Clay, G.C., Graff, J.W., Ulland, T.K.,Valadares, D., Davis, R.E., Scorza, B.M., Sudan, B., Sutterwala, F.S., and Wilson, M.E. Anti-inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis. J. Immunol., 199, 2823-2833, 2017.
Ulland, T.K.*,Song,W.*, Huang, S.C., Ulrich, J.D., Sergushichev, A., Beatty, W.L., Cairns, N.J., Kambal, A., Loginicheva, E.,Gilfillan, S., Cella, M., Virgin, H.W., Unanue, E.R., Holtzman, D.M., Artyomov, M.N., and Colonna, M. TREM2 is Required to Meet the Metabolic Demands of Microglia in Alzheimer’s Disease. Cell,170, 649-663, 2017.* indicates equal contribution. Previewed in Hong, S. and Stevens, B. Cell Metab., 26 (4), 590-591, 2017.
Cortez, V., Ulland, T.K., Bando, J., Robinette, M., Wang, Q., White, A.J., Gilfillan, S., Cella, M., and Colonna, M. SMAD4 Impedes Conversion of NK Cells into ILC1-like Cells by Curtailing Non-canonical TGFβ Signaling. Nat. Immunol., 18(9): 995-1003, 2017.
Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir, R., Ulland, T.K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., Itzkovitz, S., Colonna, M., Schwartz, M., Amit, I. Single Cell RNA-seq Identifies a Unique Microglia Type Associated with Alzheimer’s Disease. Cell, Jun 15; 169(7): 1276-1290, 2017. Featured in a Perspective in Science (356, 1123-1124, 2017) and a Preview in Cell (Jun 15 169(7): 1172-1174, 2017).
Ulrich, J.D., Ulland, T.K., Colonna, M., and Holtzman, D.M. Elucidating the role of TREM2 in Alzheimer’s disease. Neuron, Apr 19; 94(2): 237-248, 2017.
Song, W., Hooli, B., Mullin K., Jin S.C., Cella M., Ulland T.K., Wang Y., Tanzi R., Colonna M. Alzheimer’s Disease-associated TREM2 Variants Exhibit Either Decreased or Increased Ligand-dependent Activation. Alzheimer’s Dement., Apr; 13(4): 381-387, 2017. Will be featured in News and Views of Nat. Rev. Neurol.
Robinette, M.L., Bando, J.K., Song, W., Ulland, T.K., Gilfillan, S., and Colonna, M.IL-15 Sustains IL-7R-Independent ILC2 and ILC3 Development. Nat. Commun., Mar 31;8:14601, 2017.
2016
Ulland, T.K.*, Jain, N.*, Hornick, E.E., Elliott, E.I., Clay, G.C., Sadler, J., Mills, K.A.M., Janowski, A.M., Volk, A.P.D., Wang, K., Legge, K.L., Lokesh, G., Bourdi, M., Ferguson, P.J., Wilson, M.E., Cassel, S.L., Sutterwala, F.S. Nlrp12Mutation in C57BL/6J Mice Results in a Substrain-specific Defect in Neutrophil Recruitment. * indicates equal contribution. Nat. Commun., Oct; 7: 13180, 2016.
Wang, Y.*, Ulland, T.K.*,Ulrich, J.D.*, Song, W., Yuan, P., Mahan, T.E., Shi, Y., Gilfillan, S., Cella, M., DeMattos, R.B., Grutzendler, J., Cirrito, J.R., Holtzman, D.M.#, and Colonna, M.# TREM2-mediated Early Microglial Response Limits Diffusion and Toxicity of Amyloid Plaques. * indicates equal contribution. # indicates co-corresponding authors. J. Exp. Med., Apr; 213(5): 667-675, 2016. Featured on the cover.
Ulland, T.K.,Wang, Y., and Colonna, M. Regulation of Microglial Survival and Proliferation in Health and Diseases. Semin. Immunol., Dec; 27(6): 410-415, 2015.
Wang, Y., Bugatti, M., Ulland, T.K., Vermi, W., Gilfillan, S., and Colonna, M. Non-redundant Roles of Keratinocyte-derived IL-34 and Neutrophil-derived CSF1 in Langerhans Cells Renewal in the Steady-state and Skin Inflammation. Eur. J. Immunol., Mar; 46(3): 552-559, 2016.
2015
Ulland, T.K., Ferguson, P.J.,and Sutterwala, F.S. Modulation of Inflammasome Activation by Microbial Pathogens as a Survival Strategy: the Consequences of Evasion. J. Clin. Invest., Feb; 125(2): 469-477, 2015.
2014
Chen, G., Wang, X., Severo, M.S., Sakhon, O.S., Sohail, M., Brown, L.J., Sircar, M., Snyder, G.A., Sundberg, E.J., Ulland, T.K., Olivier, A.K., Andersen, J.F., Zhou, Y., Shi, G., Sutterwala, F.S., Kotsyfakis, M., Pedra, J.H.F. The Tick Salivary Protein Sialostatin L2 Inhibits Caspase-1-Mediated Inflammation during Anaplasma phagocytophilum Infection. Infect. Immun., Jun; 82(6): 2553-2564, 2014.
2013
Ulland, T.K.*, Janowski, A.M.*, Buchan, B.W., Cassel, S.L., Jones, B.D., and Sutterwala, F.S. Francisella tularensisLVS Folate Metabolism and Pseudouridine Synthase Gene Mutants Modulate Macrophage Caspase-1 Activation. Infect. Immun., Jan; 81(1): 201-208, 2013.
2011
Ulland, T.K. and Sutterwala F.S. Activation of the Inflammasome by Bacterial Pathogens. Invited book chapter for The Inflammasomes, 2011.
2010
Ulland, T.K., Buchan, B.W., Ketterer, M.R., Fernandes-Alnemri, T., Myerholz, D.K., Apicella, M.A., Alnemri, E.S., Jones, B.D., Nauseef, W.M., and Sutterwala, F.S. Cutting Edge: Mutation of FrancisellatularensismviNLeads to Increased Macrophage Absent in Melanoma 2 Inflammasome Activation and Loss of Virulence. J. Immunol., Sep 1; 185(5): 2670-2674, 2010.
2009
Iyer, S.S., Pulskens, W.P., Sadler, J.J., Butter, L.M., Teske, G.J., Ulland, T.K.,Eisenbarth, S.C., Florquin, S., Flavell, R.A., Leemans, J.C., and Sutterwala, F.S. Necrotic Cells Trigger a Sterile Inflammatory Response Through the NLRP3 Inflammasome. Proc. Natl. Acad. Sci., Dec; 106(48): 20388-93, 2009.
Moreland, J. G., Hook, J. S., Bailey, G., Ulland,T.,and Nauseef, W.M. Francisella tularensis Directly Interacts with the Endothelium and Recruits Neutrophils with a Blunted Inflammatory Phenotype. Am. J. Physiol. Lung Cell. Mol. Physio., Jun; 296(6):L1076-84, 2009.